5'-O-(4,4'-dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl] N6- benzoyl Adenosine

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5'-O-(4,4'-dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl] N6- benzoyl Adenosine

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5'-O-(4,4'-dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl] N6- benzoyl Adenosine Specification

HS Code
29349900

Melting Point
Not determined; decomposes

Density
Gram per cubic centimeter(g/cm3)

CAS No
1083074-56-5

Usage
For research and chemical synthesis only; not for drug, household, or other uses

Shelf Life
2 years under proper storage conditions

Poisonous
NO

Appearance
White to off-white powder

Structural Formula
Refer to image or chemical databases for structure

Physical Form
Solid

Shape
Crystalline

Grade
Molecular Biology Grade

Molecular Formula
C46H56N6O8Si

Purity
>98% (HPLC)

Properties
Protecting groups for 2-O and 5-O positions, suitable for oligonucleotide synthesis.

Smell
Odorless

Ingredients
5-O-(4,4-dimethoxytrityl) 2-O-[(1,1-dimethylethyl)-dimethylsilyl] N6-benzoyl Adenosine

Solubility
Soluble in DMSO, DMF, chloroform; slightly soluble in methanol

Application
Used as a protected adenosine monomer for RNA and DNA synthesis

Storage
Store at -20C, away from light and moisture in tightly sealed container

Taste
Not determined

Product Type
Nucleoside derivative

Molecular Weight
852.08 g/mol

Protective Groups
5'-O-Dimethoxytrityl (DMT), 2'-O-Tert-butyldimethylsilyl (TBDMS), N6-Benzoyl

Hazard Statements
Non-hazardous according to GHS classification

Packaging
Supplied in amber glass vials or bottles under inert gas

Handling Precautions
Handle under dry, inert atmosphere

Optical Activity
Chiral, optically active compound

Synonyms
DMT-TBDMS-Bz-Adenosine

Suitable For
RNA/DNA phosphoramidite synthesis, solid-phase oligonucleotide synthesis

Endotoxin Level
<0.1 EU/mg (if used for sensitive applications)

Stability
Stable under recommended storage, moisture sensitive

Deprotection Conditions
DMT removed with acidic conditions; TBDMS with fluoride sources (e.g., TEA·3HF or TBAF); Bz with ammonia or methylamine

Heavy Metals
<10 ppm

5'-O-(4,4'-dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl] N6- benzoyl Adenosine Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Export Market(s)
Australia, North America, South America, Eastern Europe, Western Europe, Middle East, Asia, Central America, Africa

Main Domestic Market
All India

About 5'-O-(4,4'-dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl] N6- benzoyl Adenosine

5'-O-(4,4'-dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl] N6- benzoyl Adenosine

CAS No : [104992-55-4]

M.Wt. 787.97

M.F. C44H49N5O7Si

Specification :

*Appearance: White to Off white powder,

*HPLC Purity: NLT 98%

*5'-ODMT-2'-OTBDMS Uridine (3'-Isomer): NMT 0.3%

*Residual Solvent: NMT 3.0%

*Moisture content by KF: NMT 1.0%

*1H NMR (Solvent : DMSO d6): Conforms with Structure

*LCMS: Corresponds to Mass

*APHA Test in 0.2M in DMSO: NMT 250

*Solubility: 0.2M in MDC

Optimized for Oligonucleotide Synthesis

This product features protective groups at strategic positions on the adenosine molecule, allowing stepwise deprotection essential for the construction of complex DNA and RNA oligonucleotides. Its high chemical purity ensures consistency and reliability in molecular biology research and synthesis protocols.

Controlled Deprotection and Compatibility

Each protecting group (DMT, TBDMS, Bz) is removed under distinct conditions-acidic, fluoride source, and ammonia/methylamine, respectively-enabling precise synthetic sequences. Its solubility profile makes it suitable for use in organic solvents common in solid-phase synthesis.

Safe Handling and Long-term Stability

The compound is stable if stored at -20C in a tightly sealed container protected from moisture and light. Packaged under inert gas, it is odorless and non-hazardous as per GHS standards, ensuring user safety and product longevity for up to two years.

FAQ's of 5'-O-(4,4'-dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl] N6- benzoyl Adenosine:

Q: How is 5-O-(4,4-dimethoxytrityl) 2-O-[(1,1-dimethylethyl)-dimethylsilyl] N6-benzoyl Adenosine used in oligonucleotide synthesis?

A: This compound serves as a protected adenosine monomer, providing specific protection for the 2-O and 5-O hydroxyl groups and the N6 position. Its design enables selective deprotection and coupling cycles critical to efficient RNA and DNA synthesis on solid-phase supports.

Q: What are the recommended deprotection conditions for each protective group on this molecule?

A: For this derivative, the DMT group is removed using mild acid; the TBDMS group requires a fluoride source such as TEA3HF or TBAF, and the N6-benzoyl group is cleaved with ammonia or methylamine. These conditions should be used sequentially to ensure selective removal.

Q: When should I store and handle this compound under an inert atmosphere?

A: It is essential to handle and store this compound under dry, inert gas (such as nitrogen or argon) at -20C, particularly to protect it from moisture and light, as the compound is moisture sensitive and stability may be compromised under ambient conditions.

Q: Where is this product typically applied in the laboratory?

A: This product is primarily used in research settings for the chemical synthesis of DNA and RNA oligonucleotides, especially where high purity and controlled protection/deprotection strategies are required, such as in molecular biology labs or specialized synthesis facilities.

Q: What are the main benefits of using this protected adenosine monomer?

A: The principal benefits include high purity (>98%), precise functional group protection, low endotoxin and heavy metal content, and compatibility with common oligonucleotide synthesis chemistries, ensuring reliable, high-quality results in sensitive applications.

Q: Is this compound hazardous, and are there any special precautions for disposal?

A: According to GHS classification, this product is non-hazardous. Normal laboratory safety protocols should be observed, and disposal should follow institutional chemical waste guidelines, avoiding release into the environment.

Q: How long is the shelf life and under what conditions should it be stored?

A: The shelf life is two years when the product is stored at -20C, well-sealed, and shielded from moisture and light. Proper storage preserves stability and ensures continued suitability for research and synthesis.

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