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N-Phthaloyl-L-Glutamic Anhydride

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MOQ : 50 Kilograms

N-Phthaloyl-L-Glutamic Anhydride Specification

Poisonous
Non-poisonous under recommended use

Application
Synthesis of modified peptides, pharmaceuticals, and organic intermediates

HS Code
29241990

Purity
>98%

Usage
Used as a protecting group for amino acids, peptide synthesis, chemical research

Physical Form
Solid

Structural Formula
See image or chemical structure: (Phthaloyl)O(CO)(CH2)2CH(CO)O (Phthalimide core with L-glutamic anhydride)

Density
1.5 Gram per cubic centimeter(g/cm3)

Taste
Not determined

EINECS No
231-981-8

Properties
White to off-white crystalline powder, stable under recommended storage conditions, hydrolyzes in water

Refractive Rate
Not determined

Ingredients
N-Phthaloyl-L-Glutamic Anhydride

Appearance
White to off-white crystalline powder

Product Type
Amino Acid Derivative

Shape
Crystalline

Grade
Laboratory/Industrial grade

Solubility
Practically insoluble in water; soluble in organic solvents (acetone, DMSO, DMF)

Molecular Formula
C12H7NO5

CAS No
7432-28-2

Melting Point
171-175C

Shelf Life
2 years if stored properly

Storage
Keep container tightly closed in a dry and well-ventilated place, store at 2-8C

Smell
Odorless or faint odor

Molecular Weight
245.19 g/mol

Handling
Use gloves, avoid breathing dust, handle in well-ventilated area

UN Number
Not regulated

Synonyms
N-Phthaloyl-L-Glu Anhydride; Phthaloylglutamic anhydride

EC Number
231-981-8

Packaging
Sealed HDPE bottles or glass containers, customizable on request

Hazard Class
Not classified as hazardous

Stability
Stable under recommended storage; avoid moisture

Boiling Point
Decomposes before boiling

IUPAC Name
2-benzene-1,3-dicarboxylic imido-4-carboxy-4-oxobutanoic anhydride

N-Phthaloyl-L-Glutamic Anhydride Trade Information

Minimum Order Quantity
50 Kilograms

Supply Ability
1 Kilograms Per Week

Delivery Time
1 Week

About N-Phthaloyl-L-Glutamic Anhydride

N-Phthaloyl-L-Glutamic Anhydride

Chemical Name : 2-[(3S)-tetrahydro-2,6-dioxo-2H-pyran-3-yl]-1H-Isoindole-1,3-(2H)-dione

CAS No.: 25830-77-7

Synonym : NPLGA, Phthalyl-L-glutamic acid anhydride

Molecular formula : C13H9NO5

Molecular weight : 259.21

Appearance : White to pale yellow crystalline powder

Solubility : Soluble in 1,4 dioxane, insoluble in water

Melting point : Between 196 - 201°C

Sp. opt. rotn.: Between -41° and -43° (C=3, Dioxane)

Purity by GC : Min. 99.0%

Superior Stability and Storage

N-Phthaloyl-L-Glutamic Anhydride exhibits remarkable stability under recommended storage conditions. To preserve its integrity, keep the container tightly closed and store it in a dry, well-ventilated environment at 2-8C. When properly stored, its shelf life extends up to two years, making it reliable for long-term laboratory or industrial use.

Applications in Chemical Synthesis

This compound is an essential reagent in chemical research and organic synthesis. It is widely utilized as a protecting group for amino acids, facilitating the synthesis of modified peptides and a variety of pharmaceuticals. Its high purity and excellent solubility in organic solvents like acetone, DMSO, and DMF enhance its functionality in complex synthesis protocols.

FAQs of N-Phthaloyl-L-Glutamic Anhydride:

Q: How should N-Phthaloyl-L-Glutamic Anhydride be stored for optimal stability?

A: It should be kept in a tightly sealed HDPE bottle or glass container, stored at 2-8C in a dry, well-ventilated place. Avoid exposure to moisture to maintain its stability and extend its shelf life up to two years.

Q: What are the primary uses and benefits of N-Phthaloyl-L-Glutamic Anhydride?

A: N-Phthaloyl-L-Glutamic Anhydride is primarily used as a protecting group for amino acids in peptide synthesis, and as an intermediate in the preparation of modified peptides and pharmaceuticals. Its high purity and stability ensure reliable results in chemical research and manufacturing processes.

Q: When is it necessary to use personal protective equipment while handling this compound?

A: Personal protective equipment such as gloves should always be used while handling N-Phthaloyl-L-Glutamic Anhydride. Additionally, the compound should be handled in a well-ventilated area and contact with dust should be avoided to ensure safety.

Q: Where can N-Phthaloyl-L-Glutamic Anhydride be sourced or purchased?

A: This compound is available globally through various distributors, exporters, importers, manufacturers, retailers, suppliers, traders, and wholesalers, particularly in India. Packaging options can be customized upon request.

Q: What is the process of using N-Phthaloyl-L-Glutamic Anhydride in synthesis applications?

A: In peptide synthesis, N-Phthaloyl-L-Glutamic Anhydride is used to temporarily protect amino groups, allowing selective modification or coupling. It is typically dissolved in compatible organic solvents such as DMF, DMSO, or acetone to facilitate the reaction.