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2-OTBDMS-A Bz

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2-OTBDMS-A Bz Specification

Appearance
White to off-white solid

Molecular Formula
C23H34N5O5Si

Taste
Not determined

Storage
Store at -20C, protected from moisture

Product Type
Nucleoside derivative

Physical Form
Powder

Smell
Odorless

HS Code
29349900

Ingredients
2-O-(tert-Butyldimethylsilyl)adenosine, benzoyl protected

Density
Gram per cubic centimeter(g/cm3)

Ph Level
Neutral

Shape
Crystalline

Structural Formula
(C23H34N5O5Si) structure

Grade
Research Grade

Usage
Suitable for automated DNA/RNA synthesizers

CAS No
123334-48-9

Melting Point
160170C

Molecular Weight
487.63 g/mol

Shelf Life
2 years (when properly stored)

Properties
High purity, moisture sensitive, protected nucleotide for oligonucleotide synthesis

Poisonous
Non-poisonous

Solubility
Soluble in DMSO, DMF; slightly soluble in water

Refractive Rate
Not determined

Purity
>=97%

Application
Used in oligonucleotide and RNA synthesis

Transport Condition
Ambient or cold pack as per requirement

Stability
Stable under recommended storage, hydrolyzes in presence of moisture

Sensitive to
Moisture and light

Quality Control
HPLC, NMR confirmation

Handling Precautions
Use gloves and eye protection, handle in argon or nitrogen atmosphere

Typical Package Size
100 mg, 250 mg, 1 g

2-OTBDMS-A Bz Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Export Market(s)
Western Europe, Australia, North America, Eastern Europe, Central America, Middle East, South America, Asia, Africa

Main Domestic Market
All India

About 2-OTBDMS-A Bz

2-OTBDMS-A Bz

CAS No : [104992-55-4]

M.Wt. 787.97

M.F. C44H49N5O7Si

Specification :

*Appearance: White to Off white powder,

*HPLC Purity: NLT 98%

*5'-ODMT-2'-OTBDMS Uridine (3'-Isomer): NMT 0.3%

*Residual Solvent: NMT 3.0%

*Moisture content by KF: NMT 1.0%

*1H NMR (Solvent : DMSO d6): Conforms with Structure

*LCMS: Corresponds to Mass

*APHA Test in 0.2M in DMSO: NMT 250

*Solubility: 0.2M in MDC

Key Features and Applications

2-OTBDMS-A Bz is specially formulated for use in oligonucleotide and RNA synthesis, compatible with automated DNA/RNA synthesizers. Its high purity (97%) and protective groups (Bz and TBDMS) enable precise and efficient nucleotide incorporation. This makes it an indispensable reagent for researchers requiring stringent quality and performance in molecular biology workflows.

Safe Handling and Storage Recommendations

For maximum stability and safety, 2-OTBDMS-A Bz must be handled with gloves and eye protection, in an inert gas atmosphere such as argon or nitrogen. The compound is highly sensitive to moisture and light; therefore, storage at -20C in a tightly sealed container is essential. Under these conditions, its shelf life extends up to 2 years.

FAQs of 2-OTBDMS-A Bz:

Q: How should 2-OTBDMS-A Bz be stored to maintain stability?

A: 2-OTBDMS-A Bz should be stored at -20C, protected from moisture and light, in a tightly sealed container. These precautions help preserve its stability and extend its shelf life up to two years.

Q: What is the recommended process for handling 2-OTBDMS-A Bz?

A: When handling 2-OTBDMS-A Bz, use gloves and eye protection, and perform operations under an argon or nitrogen atmosphere to avoid moisture exposure. This preserves its structural integrity and prevents hydrolysis.

Q: Where is 2-OTBDMS-A Bz commonly used?

A: This compound is primarily used in research laboratories for oligonucleotide and RNA synthesis, often in conjunction with automated DNA/RNA synthesizers for high-fidelity sequence assembly.

Q: What are the main benefits of using 2-OTBDMS-A Bz in nucleotide synthesis?

A: The main benefits include its high purity, specific protective groups that facilitate selective reactions, and compatibility with automated synthesis equipment, resulting in efficient and accurate nucleotide assembly.

Q: When is 2-OTBDMS-A Bz most effective for application in synthesis?

A: 2-OTBDMS-A Bz is most effective when used under dry conditions in controlled laboratory environments, particularly during the synthesis of modified oligonucleotides or RNA strands requiring precise protection protocols.

Q: What is the typical physical appearance and solubility of 2-OTBDMS-A Bz?

A: It appears as a white to off-white crystalline powder and is soluble in DMSO and DMF, with slight solubility in water, making it suitable for various laboratory procedures.

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