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Tosyl isocyanate

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MOQ : 50 Kilograms

Tosyl isocyanate Specification

Properties
Highly reactive; decomposes with moisture; sensitive to heat; pungent odor

Molecular Formula
C8H7NO2S

Application
Used as reagent in organic synthesis, pharmaceuticals, and agrochemicals

Taste
Not applicable (toxic)

Shape
Crystalline

Melting Point
65-69C

Structural Formula
C8H7NO2S

Product Type
Chemical Compound

Grade
Technical, Laboratory

EINECS No
223-810-8

Density
1.31 Gram per cubic centimeter(g/cm3)

Ingredients
Tosyl isocyanate (p-Toluenesulfonyl isocyanate)

Shelf Life
24 months

Physical Form
Powder

Appearance
White to off-white crystalline solid

Solubility
Reacts with water; soluble in organic solvents like dichloromethane and acetonitrile

Smell
Pungent, suffocating odor

Poisonous
YES

Purity
>98%

Molecular Weight
181.21 g/mol

Storage
Store in cool, dry place; tightly sealed; protect from moisture and heat

Usage
Employed for tosylation, isocyanate functionalization, and synthesis of sulfonylureas

CAS No
4083-64-1

HS Code
29291090

Tosyl isocyanate Trade Information

Minimum Order Quantity
50 Kilograms

Supply Ability
1 Kilograms Per Week

Delivery Time
1 Week

About Tosyl isocyanate

Tosyl isocyanate

Other Name : P-toluenesulphonyl isocyanate or PTSI

CAS NO.: 4083-64-1

Mol. Formula : C8H7NO3S

Mol. Wt.: 197.21

Appearance : Colorless transparent liquid

Purity : >98%

Color : 30max

NCO : 20.9%

Hydrogen chloride dissolved : 0.1%

Key Applications in Synthesis

Tosyl isocyanate is prominent in organic synthesis, where it facilitates tosylation reactions and isocyanate functionalization. This compound is indispensable in the production of sulfonylureas for pharmaceuticals and in the formulation of agrochemicals. Its high reactivity and selectivity make it a preferred reagent for laboratories and industrial chemists.

Safety and Handling Protocols

As a toxic and corrosive substance, Tosyl isocyanate should always be handled in a well-ventilated area using protective equipment. It decomposes with moisture and releases toxic fumes, so avoid exposure to water and incompatible substances. Store in a tightly sealed container in a cool, dry location and adhere to recommended safety phrases and transport conditions.

Storage and Shelf Life

For maximum potency and safety, keep Tosyl isocyanate in tightly closed HDPE drums away from heat and moisture. Under proper storage conditions, its shelf life extends up to 24 months. Periodically inspect containers for signs of degradation, especially in humid environments or fluctuating temperatures.

FAQs of Tosyl isocyanate:

Q: How should Tosyl isocyanate be safely handled and stored?

A: Tosyl isocyanate should be handled with appropriate protective gear (gloves, goggles, and face shield) in a well-ventilated area. Store it in a tightly sealed container, preferably HDPE drums, in a cool, dry place away from moisture, heat, and incompatible chemicals like water, alcohols, or amines.

Q: What is the main usage of Tosyl isocyanate in industry?

A: Tosyl isocyanate is extensively used as a reagent in organic synthesis, particularly for tosylation reactions, isocyanate functionalization, and the synthesis of sulfonylureas found in pharmaceuticals and agrochemicals.

Q: When should extra precautions be taken during the handling process?

A: Extra precautions are essential when transferring, opening, or weighing the product, as exposure to air and moisture can cause decomposition and the release of toxic, corrosive fumes. Use personal protective equipment and implement spill control measures during all handling steps.

Q: Where is Tosyl isocyanate typically applied or utilized?

A: Tosyl isocyanate is utilized in chemical laboratories and research industries, especially in pharmaceutical synthesis, agrochemical manufacturing, and other organic chemical productions requiring tosylation or isocyanate groups.

Q: What are the benefits of using Tosyl isocyanate in chemical synthesis?

A: Its high reactivity and selectivity allow for efficient tosylation and incorporation of isocyanate groups, leading to streamlined synthesis of complex molecules in both research and industrial applications.

Q: How is Tosyl isocyanate transported safely?

A: Tosyl isocyanate should be transported as a toxic material (UN 2811, Hazard Class 6.1) in properly labeled, sealed containers, and handled by trained personnel to prevent any accidental release or exposure.

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