About Trityl chloride
Trityl chloride
CAS No.: 76-83-5
Formula: (C6H5)3CCl
Molecular Weight: 278.78
Appearance: White to off-white crystalline powder
Solubility: Soluble in chloroform: 0.1 g/mL, clear
Melting Point: 109-112 °C(lit.)
Assay: 99% min.
Applications in Organic SynthesisTrityl chloride is widely recognized in organic chemistry for its role as a protecting group for alcohols. By temporarily blocking hydroxyl groups, it enables chemists to perform reactions with greater selectivity and prevents unwanted side reactions. Its use extends to the synthesis of various trityl derivatives, making it a staple intermediate in laboratories focused on complex molecule construction.
Safe Handling and Storage AdviceDue to its irritating properties and sensitivity to moisture, Trityl chloride should be handled with care. Always use appropriate personal protective equipment, such as gloves and eye protection. When storing, ensure containers are tightly sealed, kept in a cool and dry environment, and protected from exposure to moisture to maintain product integrity and avoid hazardous decomposition.
FAQs of Trityl chloride:
Q: How should Trityl chloride be stored for maximum shelf life?
A: To preserve its shelf life of up to two years, Trityl chloride must be stored in tightly closed containers kept in a cool, dry place away from moisture, as it decomposes on exposure to water.
Q: What precautions should be taken during handling of Trityl chloride?
A: Always avoid contact with skin and eyes by using suitable personal protective equipment such as chemical-resistant gloves and safety goggles. Work in a well-ventilated area or under a fume hood to reduce inhalation risks.
Q: Where is Trityl chloride commonly used in chemical processes?
A: Trityl chloride is primarily used in organic synthesis laboratories as a protecting group for alcohols and for preparing trityl derivatives, facilitating selective and controlled chemical reactions.
Q: What are the harmful effects of Trityl chloride exposure?
A: Trityl chloride can cause skin and eye irritation, and is harmful if inhaled or swallowed. It emits a pungent smell and requires careful handling to minimize health risks associated with its toxicity.
Q: When does Trityl chloride decompose, and what are the risks?
A: Trityl chloride decomposes on exposure to moisture and at higher temperatures, particularly at its boiling point of 360C. Such decomposition can release irritant or harmful byproducts, so maintain recommended storage conditions.
Q: How is Trityl chloride transported and packaged?
A: It is classified as a Class 9 environmentally hazardous substance and transported under UN 3077. The standard packaging is a 25 kg HDPE drum, with options for customized packaging upon request.