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5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine

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5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine

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5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine Specification

Shape
Crystalline powder

Product Type
Nucleoside derivative

CAS No
118619-50-2

Molecular Formula
C40H42N6O7

Properties
Protecting group for oligonucleotide synthesis; used in solid phase DNA synthesis

Storage
Store at -20°C, dry and protected from light

Melting Point
152-158°C

Molecular Weight
722.80 g/mol

Structural Formula
Refer to product image or chemical structure diagram

Physical Form
Powder

Usage
As a building block for automated DNA synthesis

Shelf Life
2 years

Appearance
White to off-white powder

Solubility
Soluble in DMF, DMSO, and slightly soluble in water

HS Code
29349900

Smell
Odorless

Ingredients
5-O-(4,4-dimethoxytrityl)-N2-dimethylaminomethylene-2-deoxyguanosine

Purity
> 98% (HPLC)

Ph Level
Neutral (in solution)

Poisonous
Non-poisonous

Application
Phosphoramidite DNA synthesis, oligonucleotide synthesis

Grade
Molecular Biology Grade

Synonyms
DMT-dG(N-dma)-OH

Manufacturing Method
Synthetic, chemical modification of 2'-deoxyguanosine

Transportation
Non-hazardous; no special transportation required

Sensitivity
Sensitive to moisture and light

Chemical Family
Nucleoside analog

Stability
Stable under recommended storage

Packaging
Supplied in amber glass vials, 100 mg, 250 mg, 1 g sizes

Quality Control
Each batch tested by HPLC and MS

IUPAC Name
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-dimethylaminomethylene guanosine

Spectral Data
H-NMR, C-NMR and mass spectra available on request

Hazard Statements
Not classified as hazardous

5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Export Market(s)
South America, Australia, North America, Eastern Europe, Western Europe, Middle East, Africa, Central America, Asia

Main Domestic Market
All India

About 5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine

5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine

CAS No : [40094-22-2]

M.Wt. 824.90

M.F. C43H53N8O7P

Specification :

*Appearance: White to Off White Powder

*Purity by HPLC (%Area): NLT 98.0%

*1H NMR (Solvent:DMSO d6): Conforms with structure

*LCMS: Corresponds to Mass

*Moisture Content (KF w/w): NMT 1.0%

*Residual Solvents (%w/w): NMT 3.0%

*APHA in 0.2M DMSO solution: NMT 300

*Solubility: 0.2M in DMF

Advanced Protecting Group for DNA Synthesis

5-O-(4,4-dimethoxytrityl)-N2-dimethylaminomethylene-2-deoxyguanosine is commonly used for introducing specific modifications at the guanosine site in oligonucleotide synthesis. Its DMT protective group and N2-dimethylaminomethylene modification facilitate selective incorporation during automated DNA synthesis, ensuring efficient coupling and high-yield results.

Stringent Quality Assurance

Each batch undergoes rigorous HPLC and mass spectrometric analysis to confirm purity (>98%) and chemical identity. All spectral data, including H-NMR and C-NMR, are available upon request. Its proven reliability makes it ideal for demanding research and molecular biology applications.

Safe, Stable, and Convenient Handling

This compound is classified as non-hazardous, making handling and international transportation straightforward. To preserve its stability and integrity, it is supplied in amber glass vials and should be stored at -20C, protected from moisture and light.

FAQ's of 5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine:

Q: How should 5-O-(4,4-dimethoxytrityl)-N2-dimethylaminomethylene-2-deoxyguanosine be stored?

A: Store this compound at -20C in a dry place, protected from light and moisture to maintain optimal stability and shelf life.

Q: What is the primary application of this product in molecular biology?

A: It serves as a protected nucleoside analog for use in solid phase DNA synthesis, acting as a critical building block during automated oligonucleotide assembly.

Q: When should researchers request spectral data for this compound?

A: Researchers can request H-NMR, C-NMR, and mass spectra if additional verification or quality assurance documentation is required for their experiments.

Q: Where can this product be sourced or supplied?

A: This product is available in India through distributors, exporters, importers, manufacturers, retailers, suppliers, traders, and wholesalers.

Q: What process is used to manufacture this nucleoside analog?

A: The compound is synthesized via chemical modification of 2-deoxyguanosine, ensuring high purity and suitability for sensitive DNA synthesis protocols.

Q: How does this compound benefit automated oligonucleotide synthesis?

A: The DMT protective group and N2-dimethylaminomethylene modification enhance coupling efficiency, selectivity, and the overall yield of DNA assembly reactions.