About N N-Diisopropylethylamine
N N-Diisopropylethylamine
CAS No.: 7087-68-5
Molecular Formula : (C3H7)2N C2H5
Molecular Weight : 129.24
Appearance : colorless liquid, ammonia like odor
Solubility : Water Soluble
Flash Point : 10-11 DC
Key Features of N,N-DiisopropylethylamineDIPEA is a colorless, transparent liquid with a characteristic pungent amine-like odor. It has a low density (0.742 g/cm), a boiling point of 127-129C, and demonstrates high volatility. Its strong basicity and non-nucleophilic nature are especially valuable in organic synthesis, ensuring reactivity without unwanted side reactions.
Applications in Laboratory and IndustryN,N-Diisopropylethylamine is widely employed as a base in organic reactions, peptide coupling, and manufacturing pharmaceutical intermediates. Its non-nucleophilic properties make it ideal for procedures where selectivity and minimal side reactions are crucial. The chemical is available in industrial and laboratory grades to meet diverse operational requirements.
Safe Handling and Storage TipsGiven its flash point of 12C and highly flammable nature, DIPEA should be stored in a cool, dry, well-ventilated area, tightly closed and away from ignition sources. Personal protective equipment, such as gloves and eye protection, is recommended during use to minimize the risk of skin and eye irritation. Proper storage ensures a shelf life of up to 24 months.
FAQs of N N-Diisopropylethylamine:
Q: How should N,N-Diisopropylethylamine be stored to ensure safety and stability?
A: Store the product in a cool, dry, and well-ventilated area, keeping the container tightly closed and away from heat, sparks, and open flames to maintain stability and minimize fire hazards.
Q: What is the primary benefit of using DIPEA in organic synthesis?
A: DIPEA acts as a strong, non-nucleophilic base, allowing it to facilitate reactionssuch as peptide couplingwithout interfering with sensitive functional groups, thus increasing selectivity and efficiency.
Q: Which applications commonly utilize N,N-Diisopropylethylamine?
A: DIPEA is widely used in laboratory and industrial synthesis as a base for organic reactions, peptide couplings, and the preparation of pharmaceutical intermediates due to its unique chemical properties.
Q: When should protective equipment be worn during DIPEA handling?
A: Protective gloves and eye protection should always be worn when handling DIPEA to guard against skin and eye irritation, as advised in the precautionary statements.
Q: Where can DIPEA be purchased and in what packaging options is it available?
A: DIPEA is available through distributors, manufacturers, and suppliers in India and is offered in 1L, 5L, and 25L HDPE bottles or drums to accommodate different usage needs.
Q: What process benefits does N,N-Diisopropylethylamine provide over other bases?
A: Its non-nucleophilic nature reduces unwanted side reactions, enabling cleaner and more predictable synthesis, especially valuable in multi-step organic or peptide production.