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5 -ODMT N-dmf dG (PNS)

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5 -ODMT N-dmf dG (PNS) Specification

Molecular Weight
807.88 g/mol

Storage
Store at -20°C in an airtight container under inert gas

HS Code
29349900

Product Type
Nucleoside Phosphoramidite

Shape
Crystalline

Appearance
White to off-white powder

Application
Used in DNA oligonucleotide synthesis

Solubility
Soluble in acetonitrile

Ingredients
5-O-DMT-N-dmf-2-deoxyguanosine-3-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

CAS No
142919-92-0

Shelf Life
12 months (if stored properly)

Purity
>98% (by HPLC)

Usage
Building block for automated DNA synthesizer platforms

Refractive Rate
Not determined

Smell
Odorless

Density
Gram per cubic centimeter(g/cm3)

Grade
Molecular Biology Grade

Poisonous
NO

Melting Point
Approx. 160-170 °C (decomposes)

Properties
High purity; suitable for automated DNA synthesis; moisture sensitive; requires inert atmosphere handling.

Physical Form
Powder

Taste
Odorless

Molecular Formula
C43H50N7O7P

Structural Formula
See product image for structure

Sensitivity
Moisture and light sensitive

Deprotection
Standard conditions for DMT removal and dmf deprotection apply

End Use
Laboratory R&D and diagnostics only; not for human use

Protecting Groups
5'-DMT, exocyclic N2-dmf

Pack Size
100 mg, 250 mg, 500 mg, 1 g

Compatibility
Compatible with standard phosphoramidite DNA synthesis protocols

Synonyms
5'-O-Dimethoxytrityl-N-dimethylformamidine-2'-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Handling Precautions
Use gloves and eye protection; avoid moisture exposure.

5 -ODMT N-dmf dG (PNS) Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Export Market(s)
South America, Australia, North America, Eastern Europe, Africa, Central America, Middle East, Western Europe, Asia

Main Domestic Market
All India

About 5 -ODMT N-dmf dG (PNS)

5 -ODMT N-dmf dG (PNS)

CAS No : [40094-22-2]

M.Wt. 824.90

M.F. C43H53N8O7P

Specification :

*Appearance: White to Off White Powder

*Purity by HPLC (%Area): NLT 98.0%

*1H NMR (Solvent:DMSO d6): Conforms with structure

*LCMS: Corresponds to Mass

*Moisture Content (KF w/w): NMT 1.0%

*Residual Solvents (%w/w): NMT 3.0%

*APHA in 0.2M DMSO solution: NMT 300

*Solubility: 0.2M in DMF

High-Quality Building Block for DNA Synthesis

5-ODMT N-dmf dG (PNS) plays a vital role in the synthesis of DNA oligonucleotides by serving as a protected guanosine phosphoramidite monomer. Its exceptional purity and suitability for automated DNA synthesizer platforms ensure reliable sequence assembly in research, diagnostics, and molecular biology laboratories.

Strict Sensitivity and Storage Guidelines

To preserve the integrity of this phosphoramidite, it must be stored in airtight containers under inert gas at -20C. Given its susceptibility to moisture and light, handling should take place in a controlled, dry environment with protective gloves and eyewear to maintain stability and purity throughout its shelf life.

Efficient Deprotection and Compatibility

This compound is engineered with 5-DMT and exocyclic N2-dmf protecting groups, simplifying the deprotection process by allowing the use of standard removal conditions. Its design ensures seamless integration into established phosphoramidite DNA synthesis protocols, making it a preferred choice for oligonucleotide researchers.

FAQ's of 5 -ODMT N-dmf dG (PNS):

Q: How should 5-ODMT N-dmf dG (PNS) be stored to ensure maximum stability?

A: Store this compound tightly sealed under inert gas (such as argon or nitrogen) at -20C, away from moisture and light, to maintain its stability and high purity.

Q: What is the main application of 5-ODMT N-dmf dG (PNS) in the laboratory?

A: It is primarily used as a protected guanosine phosphoramidite monomer in automated DNA oligonucleotide synthesis for research and diagnostic purposes.

Q: How is 5-ODMT N-dmf dG (PNS) compatible with standard DNA synthesis protocols?

A: This phosphoramidite is designed to integrate seamlessly with routine phosphoramidite-based DNA synthesis protocols, ensuring efficiency in oligonucleotide assembly and minimal process adjustments.

Q: What precautions should be taken when handling this product?

A: Always handle wearing gloves and eye protection in a dry environment. Avoid any exposure to moisture, and keep the material under an inert atmosphere during both usage and storage.

Q: What deprotection process is recommended for this compound?

A: Standard laboratory procedures for removal of the DMT and dmf protecting groups should be used. Follow your DNA synthesis platform's established deprotection protocols for optimal results.

Q: Where is 5-ODMT N-dmf dG (PNS) intended to be used?

A: It is intended exclusively for laboratory research and diagnostics. This product should not be used for any therapeutic or human consumption purposes.

Q: What benefits does 5-ODMT N-dmf dG (PNS) offer for oligonucleotide synthesis?

A: It offers high purity, reliable performance in automated synthesizers, compatibility with standardized protocols, and efficient deprotection, contributing to consistent yields and robust research results.

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