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2- OTBDMS-U

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2- OTBDMS-U Specification

Ingredients
2-(Trimethylsilyl)ethoxymethyl chloride (OTBDMS-Cl)

Poisonous
May be harmful if swallowed, handle with care

Shelf Life
12 months

Ph Level
Not determined

Purity
>98%

Structural Formula
(CH3)3SiCH2OC2H5

Usage
Silylation agent in protecting hydroxyl groups

EINECS No
242-055-1

Grade
Analytical Grade, Industrial Grade

Solubility
Insoluble in water, soluble in organic solvents

Physical Form
Liquid

Product Type
Organosilicon compound

Smell
Characteristic, slightly pungent

Density
0.933 Gram per cubic centimeter(g/cm3)

Appearance
Clear colorless to yellowish liquid

Storage
Store in cool, dry place, tightly closed, under inert gas

HS Code
29319090

Properties
High chemical stability, moisture sensitive, used as silylating agent

Molecular Weight
180.75 g/mol

Refractive Rate
n20/D 1.4230

Shape
Liquid form

Molecular Formula
C7H17ClOSi

Application
Used for silyl protection of alcohols and amines in organic synthesis

Melting Point
<-20C

CAS No
18162-48-6

Boiling Point
59-61C at 10 mmHg

Hazard Class
Irritant, handle with standard laboratory precautions

Synonyms
2-((tert-butyldimethylsilyl)oxy)ethyl chloride, OTBDMS-Cl

Stability
Stable under recommended storage conditions

Packaging Details
Sealed glass bottles, 1g, 5g, 25g, or customized

Sensitivity
Air and moisture sensitive

Flash Point
>110C

2- OTBDMS-U Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Export Market(s)
Australia, North America, South America, Eastern Europe, Western Europe, Middle East, Africa, Central America, Asia

Main Domestic Market
All India

About 2- OTBDMS-U

2-OTBDMS-U

CAS No : [81246-80-2]

M.Wt. 660.82

M.F. C36H44N2O8Si

Specification :

*Appearance: White to Off white powder,

*HPLC Purity: NLT 98%

*5'-ODMT-2'-OTBDMS Uridine (3'-Isomer): NMT 0.3%

*Residual Solvent: NMT 3.0%

*Moisture content by KF: NMT 1.0%

*1H NMR (Solvent : DMSO d6): Conforms with Structure

*LCMS: Corresponds to Mass

*APHA Test in 0.2M in DMSO: NMT 250

*Solubility: 0.2M in MDC

Key Features and Stability

2-OTBDMS-U excels for its high chemical stability, rendering it particularly valuable in moisture-sensitive organic synthesis processes. Its composition remains stable when kept tightly sealed under an inert atmosphere, away from moisture and air. The product's clear liquid form, combined with a density of 0.933 g/cm3 and refractive index of 1.4230, ensures consistency during sensitive procedures. The analytical and industrial grade options suit a variety of research and manufacturing needs.

Safe Handling and Storage Guidelines

Given its air and moisture sensitivity, 2-OTBDMS-U should always be handled under an inert atmosphere such as nitrogen or argon, using standard laboratory safety precautions. The product is irritant and can be harmful if ingested, making protective gear essential. Store the sealed glass bottles in a cool, dry place, tightly closed, and away from incompatible materials to maintain product quality and efficacy. Proper storage prolongs its shelf life up to 12 months.

Applications in Organic Synthesis

OTBDMS-Cl is predominantly used as a silylating agent for the protection of hydroxyl and amine groups in organic synthesis. Its solubility in organic solvents and resistance to aqueous conditions make it an optimal choice for multi-step synthetic protocols. Its usage facilitates selective transformations, protecting sensitive groups throughout complex synthesis, contributing to higher yields and cleaner reactions in both research and industrial environments.

FAQ's of 2- OTBDMS-U:

Q: How should 2-OTBDMS-U be properly handled and stored to maintain its stability?

A: Due to its sensitivity to air and moisture, 2-OTBDMS-U should always be handled in a dry, inert atmosphere such as within a glovebox or under nitrogen. It must be kept tightly sealed in its original glass bottle and stored in a cool, dry place to ensure optimal stability and extend its shelf life.

Q: What is the primary usage of OTBDMS-Cl in organic synthesis laboratories?

A: 2-OTBDMS-U (OTBDMS-Cl) is mainly used as a silylation agent to protect hydroxyl (alcohol) and amine groups during organic synthesis, preventing undesired reactions by temporarily masking these functional groups.

Q: When is it recommended to use 2-OTBDMS-U in a chemical process?

A: This reagent is best used during multi-step organic syntheses where selective protection of alcohols or amines is critical. It is introduced during the protection phase and later removed under specific conditions to reveal the original functional group.

Q: Where can I source 2-OTBDMS-U and what packaging options are available?

A: 2-OTBDMS-U is available from various suppliers, distributors, and manufacturers in India. Packaging options include sealed glass bottles of 1g, 5g, 25g, or custom quantities as per your requirements.

Q: What safety precautions should be followed when working with OTBDMS-Cl?

A: Always wear appropriate laboratory safety equipment such as gloves and goggles. Handle the compound in a fume hood, avoid contact with skin, eyes, and clothing, and never ingest. Dispose of any waste according to established hazardous chemical protocols.

Q: How does using 2-OTBDMS-U benefit organic synthesis outcomes?

A: The high selectivity and efficiency of 2-OTBDMS-U in protecting hydroxyl and amine groups contribute to cleaner reactions, higher product yields, and easier purification, particularly in complex synthetic sequences.

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