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5'-O-(4,4'-dimethoxytrityl) N2-isobutyryl-2'-deoxyguanosine,

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5'-O-(4,4'-dimethoxytrityl) N2-isobutyryl-2'-deoxyguanosine,

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5'-O-(4,4'-dimethoxytrityl) N2-isobutyryl-2'-deoxyguanosine, Specification

Molecular Formula
C40H43N5O8

Taste
Not determined

Grade
Research Grade / Synthesis Grade

Structural Formula
See: https://cpimg.tistatic.com/6520732/s/4/5-O-44-dimethoxytrityl-N2-isobutyryl-2-deoxyguanosine.jpg

Poisonous
Non-poisonous (for laboratory use, not for human consumption)

HS Code
29349900

CAS No
87799-17-1

Density
Gram per cubic centimeter(g/cm3)

Shape
Crystalline

Properties
Protected deoxyguanosine suitable for oligonucleotide synthesis, DMT protection at 5-OH, N2-isobutyryl group at exocyclic amino

Application
Phosphoramidite oligonucleotide synthesis, DNA synthesis building block

Shelf Life
12 months under recommended storage conditions

Ingredients
5-O-(4,4-dimethoxytrityl) N2-isobutyryl-2-deoxyguanosine

Smell
Odorless

Physical Form
Solid

Solubility
Soluble in DMSO, methanol, and DMF

Appearance
White to off-white powder

Molecular Weight
721.80 g/mol

Product Type
Nucleoside analogue

Melting Point
160-170°C (decomposes)

Refractive Rate
Not determined

Storage
Store at -20°C, protected from light and moisture

Purity
>=98% (HPLC)

Usage
Used in automated DNA synthesizers for the incorporation of protected guanine bases

Hazard Statements
For laboratory use only, avoid inhalation or contact with skin

Sensitive To
Moisture, prolonged exposure to light

UN Number
Not regulated

Protecting Groups
5'-O-(4,4'-dimethoxytrityl), N2-isobutyryl

Synonyms
DMT-dG(iBu)

Boiling Point
Not applicable (decomposes)

Packing
Typically packed in glass vials under inert atmosphere

Handling Precautions
Handle in dry conditions, minimize exposure to light

Stability
Stable under recommended storage

5'-O-(4,4'-dimethoxytrityl) N2-isobutyryl-2'-deoxyguanosine, Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Domestic Market
All India

About 5'-O-(4,4'-dimethoxytrityl) N2-isobutyryl-2'-deoxyguanosine,

5'-O-(4,4'-dimethoxytrityl) N2-isobutyryl-2'-deoxyguanosine,

CAS No : [68892-41-1]

M.Wt. 639.7

M.F. C35H37N5O7

Specification :

*Appearance: White to Off White Powder

*Purity by HPLC (%Area): NLT 98.0%

*1H NMR (Solvent:DMSO d6): Conforms with structure

*LCMS: Corresponds to Mass

*Moisture Content (KF w/w): NMT 1.0%

*Residual Solvents (%w/w): NMT 3.0%

*APHA in 0.2M DMSO solution: NMT 300

*Solubility: 0.2M in DMF

Precise Synthesis with Reliable Protection

With its dual protective groups-4,4-dimethoxytrityl at the 5-O position and isobutyryl at N2-this deoxyguanosine derivative ensures accurate base incorporation during automated DNA synthesis. These protections minimize side reactions and enable sequential nucleotide addition, which is essential for high-throughput oligonucleotide manufacturing.

Storage and Handling Recommendations

Maintain product efficacy by storing at -20C, shielded from light and moisture. Glass vials under inert atmosphere are standard to preserve its crystalline quality. Low humidity and minimal light exposure during handling prevent degradation, ensuring consistent results for sensitive oligonucleotide applications.

FAQ's of 5'-O-(4,4'-dimethoxytrityl) N2-isobutyryl-2'-deoxyguanosine,:

Q: What is the primary use of 5-O-(4,4-dimethoxytrityl) N2-isobutyryl-2-deoxyguanosine in research?

A: This compound is mainly used as a building block for protected guanine incorporation during automated phosphoramidite DNA synthesis, allowing precise strand assembly in oligonucleotide manufacturing.

Q: How should this product be stored to maintain stability?

A: It should be stored at -20C in a tightly sealed glass vial, protected from both moisture and prolonged light exposure to preserve its purity and structural integrity.

Q: What are the recommended handling precautions for this compound?

A: Always handle in dry conditions, minimize exposure to light, and avoid inhalation or direct skin contact. Use personal protective equipment and work within a well-ventilated laboratory environment.

Q: Why are protective groups like DMT and isobutyryl used in this molecule?

A: The 4,4-dimethoxytrityl and N2-isobutyryl groups block reactive sites, reducing unwanted side reactions and enabling sequential and accurate nucleotide addition during DNA synthesis processes.

Q: What are the benefits of using this specific protected deoxyguanosine?

A: It provides high purity and reliable protection of functional groups, ensuring efficient base incorporation and minimizing errors during machine-driven oligonucleotide synthesis.

Q: Where is this compound typically applied?

A: It is predominantly utilized in laboratory environments for DNA synthesis, especially in research institutions and biotechnology companies involved in oligonucleotide development.

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