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2-OTBDMS-G ibu

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2-OTBDMS-G ibu Specification

Grade
Research Grade

Application
Intermediate for chemical synthesis, oligonucleotide synthesis

Smell
Odorless

Molecular Weight
479.61 g/mol

Purity
>=98%

Molecular Formula
C21H33N5O6Si

Properties
Protected guanosine analogue; air and moisture sensitive

Solubility
Soluble in DMSO, DMF; slightly soluble in water

Melting Point
178-182C (dec.)

Density
Gram per cubic centimeter(g/cm3)

Physical Form
Powder

Refractive Rate
Not determined

Storage
Store at -20C, dry and dark conditions

Structural Formula
[Refer to image for structural representation]

Ingredients
2-O-(tert-Butyldimethylsilyl)guanosine, isobutyryl protected

Usage
Laboratory use only

Poisonous
NO

HS Code
29349900

CAS No
141195-86-6

Shelf Life
2 years (when stored properly)

Product Type
Chemical Compound

Shape
Crystalline

Taste
Not determined

Appearance
White to off-white solid

Impurity Level
<1%

Hazard Statements
Not hazardous under GHS classification

Stability
Stable under recommended storage conditions

Regulatory Status
For R&D use only, not for drug, household, or other purposes

Packaging
Supplied in sealed amber vials

Protecting Groups
TBDMS (2'-O-), Isobutyryl (N2-)

Synonyms
2'-O-tert-butyldimethylsilyl-N2-isobutyrylguanosine

Transport Information
Non-hazardous for air, sea, and road transport

2-OTBDMS-G ibu Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Export Market(s)
Australia, North America, South America, Eastern Europe, Western Europe, Middle East, Africa, Central America, Asia

Main Domestic Market
All India

About 2-OTBDMS-G ibu

2-OTBDMS-G ibu

CAS No : [147201-04-5]

M.Wt. 769.95

M.F. C41H51N5O8Si

Specification :

*Appearance: White to Off white powder,

*HPLC Purity: NLT 98%

*5'-ODMT-2'-OTBDMS Uridine (3'-Isomer): NMT 0.3%

*Residual Solvent: NMT 3.0%

*Moisture content by KF: NMT 1.0%

*1H NMR (Solvent : DMSO d6): Conforms with Structure

*LCMS: Corresponds to Mass

*APHA Test in 0.2M in DMSO: NMT 250

*Solubility: 0.2M in MDC

Advanced Nucleoside Protection for Synthesis

2'-OTBDMS-G ibu provides dual protection with TBDMS on the 2'-OH group and isobutyryl at N2, making it invaluable in oligonucleotide synthesis. Its high purity (98%) and stable nature ensure consistent results during complex chemical reactions in laboratory environments. This compound supports advanced research by minimizing side-reactions and degradation.

Safe Handling and Convenient Packaging

Designed specifically for laboratory use, 2'-OTBDMS-G ibu is non-hazardous under GHS and safe for air, sea, and road transport. The product is odorless, non-poisonous, and supplied as a white to off-white crystalline powder in sealed amber vials to protect it from moisture and light, ensuring maximum stability during storage and transport.

FAQ's of 2a-OTBDMS-G ibu:

Q: How should 2'-OTBDMS-G ibu be stored to maintain its stability?

A: 2'-OTBDMS-G ibu should be stored at -20C in a dry and dark environment. Proper storage in sealed amber vials will maintain its stability for up to two years.

Q: What is the primary use of 2'-OTBDMS-G ibu in the laboratory?

A: This compound is mainly utilized as an intermediate in chemical synthesis and oligonucleotide synthesis, where protected nucleoside analogues are required.

Q: When should I use 2'-OTBDMS-G ibu in my synthesis process?

A: 2'-OTBDMS-G ibu is used during steps where the guanosine moiety must be protected to prevent undesired reactions, particularly in multistep nucleotide or oligonucleotide synthesis workflows.

Q: Where is 2'-OTBDMS-G ibu commonly applied within research?

A: It is widely used in chemical research institutions, biotechnology labs, and pharmaceutical development centers focusing on advanced nucleic acid synthesis.

Q: What are the safety and regulatory considerations for handling 2'-OTBDMS-G ibu?

A: The compound is classified as non-hazardous under the GHS, and is non-poisonous and odorless. It is supplied for research and development purposes only and is not intended for drug, household, or any other use.

Q: How is 2'-OTBDMS-G ibu typically delivered and supplied?

A: It is shipped in sealed amber vials to protect from air and moisture, with impurity levels below 1%, ensuring safe and stable delivery during transport and storage.

Q: What is the benefit of using 2'-OTBDMS-G ibu with dual protecting groups?

A: The combined TBDMS and isobutyryl groups provide robust protection for guanosine, facilitating selective reactions and higher yields in complex oligonucleotide synthesis and reducing degradation during the process.

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