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Cyanogen Bromide

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MOQ : 1 Kilograms

Cyanogen Bromide Specification

HS Code
28499090

Poisonous
Yes, highly toxic

Molecular Weight
105.92 g/mol

Melting Point
52-54C

Properties
Highly toxic, reactive, used for cleaving peptides at methionine residues

CAS No
506-68-3

Taste
Not applicable (Highly toxic)

Ingredients
Cyanogen Bromide

Purity
98%

Structural Formula
Br-CN

Product Type
Inorganic Chemical

Grade
Analytical/Reagent Grade

Application
Used in protein sequencing, organic synthesis, and pharmaceutical intermediate

Shape
Crystalline

Usage
Cleavage of peptides at methionine, chemical synthesis

Molecular Formula
NCBr

EINECS No
208-056-8

Appearance
White to off-white crystalline powder

Smell
Pungent, irritating odour

Storage
Store in cool, dry, well-ventilated area, tightly closed container, away from moisture, light, and incompatible materials

Physical Form
Solid

Solubility
Soluble in water, alcohol, ether, benzene; decomposes in water

Shelf Life
2 years under recommended conditions

Density
2.02 Gram per cubic centimeter(g/cm3)

Stability
Stable under recommended storage conditions, decomposes in water

Certified By
ISO Certified Manufacturer

GHS Pictograms
Skull & Crossbones, Exclamation Mark

Hazard Class
6.1 (Toxic substance)

Environmental Hazards
Marine pollutant, dangerous to aquatic life

UN Number
UN 1889

Packing Type
Sealed glass bottle or HDPE container

Compatibility
Avoid contact with oxidizing agents, acids, bases

Safety Precautions
Use personal protective equipment, work under fume hood

Manufacturing Method
Direct reaction of bromine and cyanogen gas

Transport
Transport as Class 6.1 hazardous chemical

Signal Word
Danger

Packing Group
I

Disposal
Dispose in accordance with local, regional, national regulations

Boiling Point
61C

Regulatory Compliance
Complies with REACH, GHS guidelines

First Aid Measures
Immediate medical attention required in case of exposure

Vapor Pressure
70 mm Hg at 25C

Cyanogen Bromide Trade Information

Minimum Order Quantity
1 Kilograms

Supply Ability
1 Kilograms Per Week

Delivery Time
1 Week

About Cyanogen Bromide

Cyanogen Bromide

Other Name : Bromine cyanide

Molecular Formula : CNBr

Molecular Weight(Mass): 105.93gm/mole

Appearance : White crystalline compound

Assay : 97%

Solubility : Soluble in water

Melting range : 48-50C

CAS Number : 506-68-3

Key Properties and Composition

Cyanogen Bromide has the molecular formula NCBr and a molecular weight of 105.92 g/mol. It appears as a white to off-white crystalline powder with a pungent, irritating odor. Marked by high toxicity (Hazard Class 6.1), it is soluble in water, alcohol, ether, and benzene, but decomposes when exposed to water. Its purity is rated at 98%, making it suitable for analytical and reagent-grade applications.

Safe Handling and Storage

Due to its poisonous and reactive nature, Cyanogen Bromide should only be handled using personal protective equipment and within a well-ventilated fume hood. Store it in tightly sealed glass or HDPE containers in a cool, dry, well-ventilated area, away from moisture, light, and incompatible materials. It remains stable under recommended conditions, with a shelf life of up to two years.

Hazards, Environmental Impact, and Regulatory Compliance

Cyanogen Bromide carries significant health and environmental risks: it is toxic, causes marine pollution, and threatens aquatic life. It must be transported as a Class 6.1 hazardous chemical (Packing Group I), and immediate medical attention is needed if exposed. Disposal must align with local, regional, and national regulations. The product complies with REACH, GHS guidelines, and is manufactured by certified ISO suppliers.

Applications and Benefits

Widely used for cleaving peptides at methionine residues, Cyanogen Bromide is essential to protein sequencing, chemical synthesis, and the pharmaceutical industry. Its high purity ensures consistent analytical results and effective performance in specialized reactions, providing significant benefit to research and development sectors.

FAQs of Cyanogen Bromide:

Q: How should Cyanogen Bromide be safely stored and handled?

A: Cyanogen Bromide should be stored in a tightly closed glass or HDPE container within a cool, dry, and well-ventilated area, protected from moisture, light, and incompatible substances like oxidizing agents, acids, and bases. Always handle it using appropriate personal protective equipment and work inside a fume hood to avoid inhalation and accidental exposure.

Q: What is the recommended usage of Cyanogen Bromide in laboratory applications?

A: Cyanogen Bromide is primarily used for cleaving peptides at methionine residues during protein sequencing, and is also utilized in organic synthesis and as a pharmaceutical intermediate. Its high reactivity allows for precise molecular modifications, making it invaluable for analytical and synthetic chemistry procedures.

Q: When is it necessary to seek medical attention if exposed to Cyanogen Bromide?

A: Immediate medical attention is required after any exposure to Cyanogen Bromide due to its extreme toxicity. Symptoms such as irritation, respiratory distress, or any abnormal physical response after exposure demand prompt professional medical evaluation and treatment.

Q: Where should Cyanogen Bromide waste be disposed of?

A: All waste containing Cyanogen Bromide must be disposed of following local, regional, and national regulations for hazardous substances. Never pour the compound down the drain or dispose of it with regular laboratory waste due to its environmental toxicity, especially to aquatic life.

Q: What process is used for manufacturing Cyanogen Bromide?

A: Cyanogen Bromide is produced through the direct reaction of bromine and cyanogen gas under controlled industrial conditions. This process yields a highly pure, crystalline solid suitable for analytical and industrial applications.

Q: How can users benefit from employing Cyanogen Bromide in protein research?

A: The primary benefit of using Cyanogen Bromide in protein research lies in its ability to selectively cleave peptide bonds at methionine residues, facilitating protein sequencing and mapping. Its high reactivity and purity contribute to precise analytical outcomes and efficient peptide modification.

Q: What transport and regulatory measures must be followed with Cyanogen Bromide?

A: Cyanogen Bromide should be transported as a Class 6.1 toxic hazardous chemical (UN 1889), in compliance with REACH and GHS guidelines, using certified sealed containers and by trained professionals only. Ensure that all shipping documentation and hazardous material protocols are strictly followed.

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