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Colchicine

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MOQ : 1 Gram

Colchicine Specification

Structural Formula
[See molecular structure: https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=6167&t=l]

Usage
Pharmaceutical preparations; research

Shelf Life
2 years

Physical Form
Solid

Application
Used in the treatment of gout and familial Mediterranean fever

Grade
Pharmaceutical Grade

Solubility
Soluble in water, ethanol, chloroform

Molecular Weight
399.44 g/mol

Density
1.42 Gram per cubic centimeter(g/cm3)

Properties
Alkaloid; Antigout agent; Inhibits microtubule polymerization

Shape
Crystalline

Storage
Store in cool, dry, well-ventilated area

Product Type
Pharmaceutical Raw Material

EINECS No
200-598-5

Poisonous
YES

Melting Point
157-158C

Appearance
White to pale yellow crystalline powder

Ingredients
Colchicine

Smell
Odorless

Taste
Bitter

CAS No
64-86-8

Purity
98.0%

Molecular Formula
C22H25NO6

HS Code
29420090

Colchicine Trade Information

Minimum Order Quantity
1 Gram

Supply Ability
1 Gram Per Week

Delivery Time
1 Week

About Colchicine

Colchicine

Molecular Formula : C22H25NO6

Molecular Weight(Mass): 399.45gm/mole

Appearance : Pale yellow powder

Assay (anhydrous,UV) : 98%

Solubility : 10% solution in methanol & 2% aq. soln. is clear and pale yellow

Melting range : 147-150C

Application : Used in research in plant genetics for doubling chromosome

CAS Number : 64-86-8

Therapeutic Applications and Benefits

Colchicine is primarily utilized in pharmaceutical preparations for managing gout and familial Mediterranean fever, thanks to its unique mechanism of inhibiting microtubule polymerization. Its anti-inflammatory action provides effective relief from acute symptoms and helps prevent recurring flare-ups, enhancing patient quality of life.

Physical Characteristics and Storage

With high crystallinity and optical activity, Colchicine appears as a white to pale yellow, odorless, bitter crystalline powder. It maintains stability and potency when stored at 28C in a cool, dry, and well-ventilated area, using HDPE drums or glass bottles for safe containment.

Safety and Regulatory Compliance

Colchicine is toxic if swallowed or inhaled and must be handled with care. It is regulated under US FDA for specific indications, identified as UN1544 for transportation, and holds EC No 200-598-5. It is distributed in India by reputable suppliers, manufacturers, and traders as a pharmaceutical raw material.

FAQs of Colchicine:

Q: How should Colchicine be stored to maintain its stability and potency?

A: Colchicine should be stored at a temperature of 28C in a cool, dry, and well-ventilated space. Proper storage in HDPE drums or glass bottles helps preserve its crystalline form and chemical integrity for up to two years.

Q: What are the primary therapeutic uses and benefits of Colchicine?

A: Colchicine is mainly used to treat gout and familial Mediterranean fever. Its anti-inflammatory properties help reduce the frequency and severity of flare-ups by inhibiting microtubule polymerization in affected tissues.

Q: When should medical attention be sought after exposure to Colchicine?

A: If Colchicine is accidentally ingested, seek medical attention immediately due to its high toxicity. It is also hazardous if inhaled, so avoid exposure and handle with appropriate protection.

Q: Where is Colchicine distributed and in what packaging types?

A: Colchicine is distributed globally with a focus on India, packaged primarily in HDPE drums or glass bottles for safe storage and transportation, as per regulatory guidelines.

Q: What is the process of handling Colchicine as a raw material for pharmaceutical preparations?

A: As a pharmaceutical grade raw material, Colchicine is managed under strict regulatory and safety protocols. It is kept in sealed containers, processed in controlled environments, and handled by trained personnel to avoid accidental exposure.

Q: How is Colchicine used in pharmaceutical research and development?

A: Colchicine is used as a research compound to study its effects on microtubule polymerization, investigate antigout mechanisms, and develop therapeutic formulations for FDA-approved indications.

Q: What precautions should be taken due to the hazardous nature of Colchicine?

A: Colchicine is poisonous and toxic if swallowed or inhaled. Protective equipment such as gloves and masks should be used during handling, and it should be stored away from food and chemicals not compatible with its properties.

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